I just got a call from the helpdesk that a tech wasn’t able to install from an MSI on the apps share from a file server. I checked his share & security permissions (OK) he could install other MSIs(OK)

I copied the file to the workstation he was working on and still the same error. Whelp, it’s not the share. Checked that he was in the local admins group on that Windows 10 workstation (OK) had him reboot and still no go. He was not able to run the MSI on this system. I had him launch an command prompt as administrator, browse to where I put the MSI and had him install using msiexec.

msiexec /a "NameOfInstaller.msi"

The /a option means to install it as administrator. It worked for him.